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Article Details
Clinical Image
Volume 3, Issue 4 (April Issue)

A Case of Localised Breast AL Kappa type Amyloid Deposition

Claire Comerford1*, Martin J O’Sullivan2, Brian Pierce3, Alissa Connors2, Linda Feeley3 and Oonagh Gilligan1

1Department of Haematology, Cork University Hospital, Cork, Ireland
2Department of Breast and General Surgery, Cork University Hospital, Cork, Ireland
3Department of Pathology, Cork University Hospital, Cork, Ireland

*Corresponding author: Claire Comerford, Department of Haematology, Cork University Hospital, Cork, Ireland, E-mail: claire.comerford@ucdconnect.ie

Received: April 07, 2021; Accepted: April 14, 2021; Published: May 05, 2021

Citation: Comerford C, J O’Sullivan M, Pierce B, et al. A Case of Localised Breast AL Kappa type Amyloid Deposition. Clin Image Case Rep J. 2021; 3(4): 157.

Abstract

A 64 year old lady presented for routine mammogram at which a left breast lump was isolated. Subsequent biopsy of this lesion surprisingly showed Amyloid light chain (AL) kappa type amyloidosis. Further investigations did not show any evidence of systemic amyloidosis on bone marrow trephine, Serum amyloid P component scintigraphy, echocardiogram or serum free light chain assay and thus she was diagnosed with localised breast AL amyloidosis. Interestingly, she clinically displayed mild macroglossia which can be associated with Sjogren’s syndrome which has an established association with amyloid deposition of the breast. Here we display images of the initial screening mammogram and the subsequent diagnostic breast biopsy. Breast amyloidosis is a very rare phenomenon and has only been reported as individual case reports or small case series. It is usually reported in conjunction with additional haematological malignancies, thus making this case of localised Breast AL Kappa type Amyloid deposition even more unusual.