Background: COVID 19 infections has been associated with invasive fungal infections in immunocompromised patients and those given immunomodulating medications to help treat COVID 19. These fungal infections have a high mortality and often require emergent and extensive surgical debridement. We present a case where an immunocompetent young female patient that did not receive any interventions for her COVID 19 infection and had resolution of her respiratory symptoms, but eventually succumbed to mucor rhinosinusitis.

Case Presentation: In this case report, we describe a 41-year-old unvaccinated female with recent COVID 19 infection. The patient was initially monitored in the outpatient setting but developed invasive fungal rhinosinusitis, which led to a precipitous clinical decline despite multiple surgical debridements, eventually resulting in death within days.

Conclusions: The patient in this report had no treatment for COVID 19 that might have caused iatrogenic immunomodulation. It is the authors’ contention that the patient’s COVID-19 infection contributed to mucosal sloughing, which, in conjunction with diabetic status, facilitated fungal angioinvasion that progressed into invasive fungal sinusitis.

Keywords: COVID-19; Mucor; Rhizopus; Invasive rhinosinusitis; Diabetic complications