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Article Details
Clinical Image
Volume 5, Issue 1 (January Issue)

Diffuse Large B-Cell Lymphoma Presenting with Large Adrenal Masses

Samah Nawar1 and Suhaib Radi1,2,3*

1Department of Internal Medicine, Division of Endocrinology, King Abdulaziz Medical city, Ministry of the National Guard-Health Affairs, Jeddah, Saudi Arabia

2College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia

3King Abdullah International Medical Research Center, Jeddah, Saudi Arabia

*Corresponding author: Suhaib Adel Radi, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Centre, Department of Internal Medicine, Division of Endocrinology, Ministry of the National Guard-Health Affairs, Jeddah, Saudi Arabia. E-mail: suhaibradi@gmail.com

Received: December 25, 2022; Accepted: January 04, 2023; Published: January 15, 2023

Citation: Nawar S, Radi S. Diffuse Large B-Cell Lymphoma Presenting with Large Adrenal Masses. Clin Image Case Rep J. 2023; 5(1): 295.


A 56- year -old man presented to the hospital with generalized fatigue, anorexia, nausea and vomiting for the last two months. This was associated with an unintentional weight loss of 30kg. On physical examination he was hypotensive, tachycardiac, and dehydrated. Laboratory evaluation confirmed primary adrenal insufficiency. Imaging studies are described above. Histopathology from a CT-guided biopsy of the adrenal mass was consistent with diffuse large b-cell lymphoma. Immunohistochemistry studies showed tumor cells that are strongly and diffusely positive for CD45, CD20, PAX5, and BCL6. Ki67 proliferation index was >95%. Further work-up of these adrenal masses was negative for catecholamine excess and hyperaldosteronism. The patient was started on glucocorticoid replacement for the adrenal insufficiency and chemotherapy for his lymphoma.

The differential diagnosis for adrenal nodules is large containing both benign and malignant conditions. Benign causes include, adrenal adenoma, congenital adrenal hyperplasia, infectious and infiltrative diseases. Malignant conditions, on the other hand, are associated with much poorer prognosis such as, adrenocortical carcinoma, pheochromocytoma, metastasis from solid malignancy, and the rare occurrence of primary adrenal lymphoma [1]. The co-occurrence of primary adrenal insufficiency is even more infrequent and requires destruction of 90% of the glands [1]. Diagnosis can be challenging due to nonspecific clinical manifestation and radiological features; and pathological examination is required to confirm the diagnosis [2]. The mainstay of treatment is R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy. The prognosis is generally poor with a median survival of around 1 year [2].

In conclusion, primary adrenal lymphoma can present with large adrenal masses, especially in the presence of primary adrenal insufficiency, and can be mistaken radiologically for adrenocortical carcinoma. Biopsy is imperative to guide therapy.