Tirofiban is an anti GPIIb/IIIa drug that has been widely used to decrease thrombus burden during ST elevation myocardial infarction (STEMI) angioplasty. However, the co-administration of an intravenous and intracoronary dose of Tirofiban, along with a deferred angioplasty strategy is rarely adopted. Herein, we present a case series of 6 STEMI patients with large thrombus burden, treated by deferred stenting and Tirofiban administration. The clinical outcome of those patients can so be improved by reducing the risk of slow and no flow.

Keywords: Tirofiban; Deferred angioplasty; Intracoronary; STEMI