Edwards syndrome, or trisomy 18, is a genetic disorder characterized by the presence of an extra chromosome 18, occurring in 1 in 6000 live births. This article presents the case of a female patient with clinical features of Edwards syndrome and severe complications. Her findings included clinical features of Edwards syndrome such as low-set ears, micrognathia and clenched fists with overlapping fingers. Upon arriving at Hospital Dr. Robert Reid Cabral, she was in marked respiratory distress, leading to prompt admission to the neonatal intensive care unit. Her condition of Edward’s syndrome caused serious cardiac malformations, resulting in cardiac failure. Despite appropriate treatment, the patient's condition remained unstable until she eventually stabilized enough to be discharged, but her prognosis remains reserved.

Keywords: Edward’s syndrome; Cardiac failure; Syndromic facies; Hypoglycemia; Nosocomial infection