Non-Bacterial Thrombotic Endocarditis in the Setting of Stage IV EGFR-Positive Lung Cancer

Case Report

Volume 5, Issue 7 (July Issue)

Non-Bacterial Thrombotic Endocarditis in the Setting of Stage IV EGFR-Positive Lung Cancer

Rachel Alexander^1*, Shivani Shah², Ramya Vasireddy³, Pragnan Kancharla⁴ and Gene Finley⁴

¹Allegheny Health Network Clinical Campus, Lake Erie College of Osteopathic Medicine
²Department of Medicine, Allegheny General Hospital
³Department of Medicine, Medstar Union Memorial Hospital
⁴Department of Hematology-Oncology, Allegheny General Hospital

^*Corresponding author: Rachel Alexander, Lake Erie College of Osteopathic Medicine, Allegheny Health Network, 320 E. North Avenue, Pittsburgh, PA. E-mail: Ralexander99040@med.lecom.edu

Received: June 05, 2023; Accepted: June 16, 2023; Published: July 25, 2023

Citation: Alexander R, Shah S, Vasireddy R, et al. Non-Bacterial Thrombotic Endocarditis in the Setting of Stage IV EGFR-Positive Lung Cancer. Clin Image Case Rep J. 2023; 5(7): 333.

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Abstract

A 58-year-old male initially presented to the hospital with deep vein thrombosis, pulmonary embolism and cerebral infarctions ultimately leading to diagnosis of metastatic epidermal growth factor receptor (EGFR) positive lung cancer, likely in the setting of marantic endocarditis. He was then treated under the FLAURA-2 trial and received chemotherapy (cisplatin and pemetrexed) plus Osimertinib. The patient did initially sustain clinical and radiographic response with treatment. However, he later developed recurrent cerebrovascular events, which temporally coincided with progression of the patient’s lung cancer. This subsequently led to the diagnosis of non-bacterial thrombotic (NBTE) or marantic endocarditis pertaining to not only initial diagnosis of patient’s EGFR mutated pulmonary malignancy, but also correlated with progression of disease.

Keywords: EGFR-positive Lung Cancer; Non-bacterial thrombotic endocarditis; Marantic endocarditis; Malignancy