A 26-year-old female came to our clinic with hyperkeratotic warts on the sole of the left foot. The patient informed us that the lesions had appeared spontaneously six months before. Physical examination showed several greenish, irregular, verrucous, hyperkeratotic papules, and nodules on the plantar surface of the left foot. The lesions were painless and hardened to palpation with mild itching. The histological analysis was characterized by acanthosis, parakeratosis and koilocytic cells. The clinical diagnosis was plantar papilloma, a benign illness caused by human papillomavirus (HPV) subtypes 1, 2, 4, 7, 57 or 60. The diagnosis is predominantly clinical, but recently the use of dermoscopy has augmented the identification of these lesions. The patient was treated with a topical solution of salicylic acid and lactic acid with good response. However, it is not possible to envisage when the skin lesions will recur.