We report a case of a 26-year old, farmer, with a 3-month history of a rapidly progressing left hypochondrial mass. This was associated with abdominal pain and intermittent fever. He had no history of trauma, infective endocarditis or tuberculosis and, was neither human immunodeficiency virus (HIV) positive nor diabetic. A full blood count revealed a low haemoglobin level (Hb 6.1 g/dl), a leucocytosis of 16.5 x 10⁹/l , and, a normal platelet count of 307 x 10⁹/l . Physical examination demonstrated a tender splenomegaly extending to the umbilicus (Hackett’s 4). There was no associated lymphadenopathy and cardiovascular examination was normal. An abdominal ultrasound scan suggested a splenic abscess. Following the transfusion of 2 units of whole blood, he underwent a difficult splenectomy of a large necrotic fluid- filled spleen which was densely adherent to the tail of the pancreas, inferior surface of the liver and greater curve of the stomach (Figure 1). Macroscopically, the resected spleen was large, multiloculated with total parenchymal destruction (Figure 2). He made good recovery and was discharged a week later after receiving vaccines against the encapsulated bacterial organisms, Streptocococcus pneumonia, Haemophilus influenza and Neissieria meningitides that may cause an overwhelming post splenectomy infection (OPSI).