Long-Term Effects of Intravitreal Bevacizumab on Sperm Concentration, Morphology, and Motility: A Case Report

Case Report

Volume 7, Issue 4

Long-Term Effects of Intravitreal Bevacizumab on Sperm Concentration, Morphology, and Motility: A Case Report

Maxwell S. Stem^1*, Devon A. Hughes² and Daniel R. George³

¹Pennsylvania Retina Specialists, PC; Camp Hill, PA
²Department of Ophthalmology, Pennsylvania State University College of Medicine; Hershey, PA
³Department of Humanities and Public Health Sciences, Pennsylvania State University College of Medicine; Hershey, PA

^*Corresponding author: Maxwell S. Stem, Pennsylvania Retina Specialists, PC; Camp Hill, PA. E-mail: maxstem@gmail.com

Received: May 16, 2025; Accepted: May 29, 2025; Published: June 15, 2025

Citation: Maxwell S. Stem, Devon A. Hughes, Daniel R. George. Long-Term Effects of Intravitreal Bevacizumab on Sperm Concentration, Morphology, and Motility: A Case Report. Clin Image Case Rep J. 2025; 7(4): 560.

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Long-Term Effects of Intravitreal Bevacizumab on Sperm Concentration, Morphology, and Motility: A Case Report

Abstract

The long-term effects of anti-vascular endothelial growth factor injections on sperm concentration, motility, and morphology have not been studied extensively. This report describes a case of a 40-year-old man being treated with intravitreal bevacizumab who also happened to be undergoing concurrent longitudinal sperm analyses. Sperm analyses were performed before and after the patient’s treatment with intravitreal bevacizumab. There were no quantitative or qualitative sperm changes following multiple intravitreal bevacizumab injections. Although intravitreal anti-vascular endothelial growth factor agents can cause systemic side effects, treatment with bevacizumab does not seem to have a significant long-term effect on sperm motility, concentration, or morphology.

Keywords: Bevacizumab; Vascular endothelial growth factor (VEGF); Fertility; Sperm; Intravitreal