The long-term effects of anti-vascular endothelial growth factor injections on sperm concentration, motility, and morphology have not been studied extensively. This report describes a case of a 40-year-old man being treated with intravitreal bevacizumab who also happened to be undergoing concurrent longitudinal sperm analyses. Sperm analyses were performed before and after the patient’s treatment with intravitreal bevacizumab. There were no quantitative or qualitative sperm changes following multiple intravitreal bevacizumab injections. Although intravitreal anti-vascular endothelial growth factor agents can cause systemic side effects, treatment with bevacizumab does not seem to have a significant long-term effect on sperm motility, concentration, or morphology.

Keywords: Bevacizumab; Vascular endothelial growth factor (VEGF); Fertility; Sperm; Intravitreal