Sebaceous hyperplasia (SH) is a benign proliferation of sebaceous glands that can pose aesthetic concerns and treatment challenges, especially in renal transplant recipients, where lesions may be larger and more diffuse. This report presents a 33-year-old male, 18 years post-kidney transplant, with a two-year history of facial papules on an immunosuppressive regimen of cyclosporine, prednisone, and mycophenolate. Treatment with isotretinoin 10 mg daily resulted in significant improvement. Isotretinoin, known for its antiproliferative and sebostatic effects, has demonstrated safety and efficacy without impacting renal function. This case supports low-dose isotretinoin as a potential treatment for SH in renal transplant patients.

Keywords: Isotretinoin; Renal transplant; Immunosuppression; Sebaceous hyperplasia; Sebaceous hyperplasia treatment; Sebaceous hyperplasia treatment in immunosuppressed patients