Pemphigus is a group of autoimmune blistering disorder characterized by intra-epithelial blisters in the skin and/or mucosa. Pemphigus foliaceus (PF) is one of the less common variants. Only a limited cases of onset or flare of pemphigus after receiving vaccination against Covid-19, have been reported in the literature so far. The diagnosis is made via direct or indirect immunofluorescence and histopathologic investigations complemented by serum IgG antibodies in the setting of appropriate clinical presentation. There is no consensus on treatment guidelines due to limited literature but Rituximab (RTX) and/or intravenous immunoglobulins are considered the treatment of choice. We are reporting a case of PF with symptoms onset 2 weeks after receiving m-RNA Covid vaccine. The patient had a good response to RTX and methylprednisolone.

Keywords: Pemphigus; Pemphigus foliaceus; Covid-19 mRNA vaccine; Vaccine-induced pemphigus foliaceus